Prof. Dr. Johan Winne
Prof. Johan Winne received his MSc in chemistry in 2000 at Ghent University, where he also obtained his PhD degree in 2007, having studied cationic polyene cyclisations under the guidance of Prof. Pierre De Clercq. He then spent two years as a postdoctoral research fellow with Prof. Gerry Pattenden in the University of Nottingham (UK), working on the total synthesis of terpenoid natural products. In 2009, he was appointed as a doctor-assistant (30% teaching position) at Ghent University, where he acquired an independent position in 2013, and in october 2015, he was appointed as a full time independent faculty member (tenure track docent). His research interests are in organic synthesis, ranging from architecturally complex natural products, to functional and modular molecular building blocks for material science and biology research.
PhD students
Hilde Janssens
BSc/MSc chemistry, Ghent University, 2019
Postdocs
Undergraduate students
Hannes Vandeputte
BSc chemistry, Ghent University, 2021
Former PhD students
Tengrui Yuan (2022)
Stereoselective synthesis of odd-membered carbocycles via sulfur-stabilized allyl cation cycloaddition and its application in natural product
Brenda Callebaut (2021)
Spicing up terpenes : rapid chemical assembly approaches and aza-analoging of evolutionary conserved ent-kauranoid scaffolds
Mien Christiaens (2020)
A Tale of Terpenes: modular synthesis strategies for natural cycloheptanoid scaffolds via cationic (4+3) cycloadditions
Bram Denoo (2019)
The private life of small molecules : elucidating their molecular mechanisms in plants and in cycloadditions
Copromotor: prof. Madder
Jan Hullaert (2018)
Concise and modular synthesis of natural product scaffolds by heterocycle-mediated cationic cycloaddition reactions
Copromotor: Kurt Hoogewijs
Duchan Laplace (2015)
Total synthesis of biologically active polycyclid terpenoids: frondosanes, liphaganes, guaianolides, zizaanes and calcitriols
Copromotor: prof. De Clercq
Former undergraduate students
Marthe Vermeulen (2023)
Heterocycle-tethered polyene cascade cyclisation towards bicyclic natural product scaffolds
Hannes Vandeputte (2023)
Synthesis of TTX inspired guanidine scaffolds via cationic cascade cyclizations
Sean Verschaeve (2022)
Synthetic and Catalytic Study of Novel Stereosecelctive Vinylcyclopropanations
Arne Ruyloft (2022)
Novel synthesis of azulene-type dyes
Jonas Van De Velde (2022)
Exploring the 5,6-dihydro-1,4-dithiin heterocycle in dearomative cycloadditions
Zjef Debrouwere (2021)
Synthesis of spirocyclic alkaloid scaffolds via tandem olefination and cyclopent-annulation of (hetero)cyclic ketones
Bram Ach (2020)
Rapid aza-analoging of common carbocyclic scaffolds via Diels-Alder/retro-Diels-Alder approach
Ellen Demeyere (2020)
Non-photochemical (2+2) cycloadditions for the assembly and decoration of common plant metabolite scaffolds
Ewout Van de Velde (2020)
Dearomative cycloadditions on indoles and a formal synthesis of phalarine
Kevin Bevernaege (2019)
Tandem functionalization of dienes as a rapid entry into N-heterocyclic scaffolds
Frederick Degroote (2019)
Novel cyclopentannulations: investigating the synthetic utility of sulfur-mediated (3+2) cycloadditions
Bram Ryckaert (2017)
Novel application of sulfurstabilized allyl-cation equivalents for (3+2) cycloaddition Reactions in natural product synthesis
Bram Bode (2017)
Synthesis towards the cyathane scaffold via an intramolecular (4+3)-cycloaddition reaction
Andreas Luttens (2017)
Conformational analysis of evolutionary conserved terpene-ring systems in a search for privileged new scaffolds
Brenda Callebaut (2016)
synthesis of the tetracyclic kaurane-type diterpene scaffold using an intramolecular (4+3) cycloaddition reaction
Mien Christiaens (2015)
The enantioselective synthesis of novel polycyclic scaffolds inspired on daucane sesquiterpenes using an intramolecular (4+3) cycloaddition
Jan Hullaert (2014)
Natural products as inspiration for drug discovery: synthesis of the scaffold of cytotoxic guaianolides using an intramolecular (4+3) cycloaddition reaction
Bart Verbraeken (2012)
Synthesis of analogues of frondosin B and liphagal, formal total synthesis of frondosin B
Bram Denoo (2012)
Biomimetic drug discovery: exploration of oxidative variations of polycyclic carbon skeletons
Duchan Laplace (2010)
Synthesis of building blocks for calcitriol analogues using a 6π-electrocyclisation